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Deciphering the Role of V88L Substitution in NDM-24 Metallo-β ... - MDPI

Compared with NDM-5 (V88L and M154L), NDM-20 (V88L, M154L, and R270H) improves the hydrolysis activity of some penicillins and cephalosporins but inhibits the activity of carbapenems, which may...

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Proportions of various secondary structural elements in the NDM-1 ...

V88L generated a destabilized effect on NDM-24. The V88L substitution occurred in the β-strand and low β-sheet content in the secondary structure, as evidenced by the CD analysis data.

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Deciphering the Role of V88L Substitution in NDM-24 Metallo-β ... - MDPI

Experimental studies have shown that the affinity of NDM-17 (V88L, M154L, and E170K) for all β-lactams is significantly higher than that of NDM-5 (V88L and M154L), and the increase in its catalytic activity may be related to the novel substitution of E170K.